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pentobarbital will minimize the extent or impact of alfuzosin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can lessen panobinostat concentrations by ~70% and bri